DRU Cymru Studies - Abertawe Bro Morgannwg University

  • Title: A Phase 2, Placebo-Controlled, Double-Blind, Enriched Enrollment, Randomised Withdrawal Study to Evaluate the Efficacy and Safety of BIIB074 in Treating Pain Experienced by Subjects with Confirmed Small Fibre Neuropathy that is Idiopathic or Associated with Diabetes Mellitus
    Acronym: CONVEY
    Recruitment Site: Morriston Hospital
    Investigator: Prof S Bain
    Contact Details: 

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  • Title: A Pragmatic Randomized Trial to Evaluate the Comparative Effectiveness Between Dapagliflozin and Standard of Care in Type 2 Diabetes Patients
    Acronym: The DECIDE Study
    Recruitment Site: Bron-Y-Garn Surgery; Glyncorrwg Health Centre; Sketty & Killay Medical Centre
    Investigator: Dr M Goodwin; Dr S Medlicott; Dr M Seager
    Contact Details: 

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  • Title: A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study Assessing the Effect of Gelesis200 on Body Weight in Overweight and Obese Subjects without or with Type 2 Diabetes
    Acronym: LIGHT-UP: Loss of weight in prediabetes and type 2 diabetes
    Recruitment Site: Morriston Hospital
    Investigator: Prof J Stephens
    Contact Details: 

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  • Title: A randomized, double-blind, placebo-controlled, parallel-group, multicentre study to demonstrate the effects of Sotagliflozin on cardiovascular and renal events in patients with type 2 diabetes, cardiovascular risk factors and moderately impaired renal function
    Acronym: The SCORED Trial
    Recruitment Site: Singleton Hospital
    Investigator: Prof S Bain
    Contact Details: 

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  • Title: Assessment of functional capacity and its association to perioperative stress evaluated via glycaemic and cardiovascular variability - a pilot study
    Acronym: Association of fitness and physical stress with metabolic surgery
    Recruitment Site: Singleton Hospital
    Investigator: Mr J Barry
    Contact Details: 

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  • Title: Can the introduction of rapid and automatic Ankle Brachial Pressure and Pulse Volume measuring device into General Practice identify the presence or absence of Peripheral Arterial Disease in cardiovascular risk groups?
    Acronym: Primary Care Screening for PAD in at risk groups
    Recruitment Site: Partner Oak Surgery; Sketty & Killay Medical Centre; St Thomas Surgery & West Cross Medical Centre
    Investigator: Dr M Davies; Dr I O'Connor; Dr M Seager
    Contact Details: 

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  • Title: Feasibility of faecal microbiotia transplantation in the management of obesity and type 2 diabetes
    Acronym: FMTODM
    Recruitment Site: Singleton Hospital
    Investigator: Prof D Harris
    Contact Details: 

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  • Title: Immune cell Studies in Type 1 Diabetes
    Acronym: ISTID
    Recruitment Site: Morriston Hospital
    Investigator: Prof S Bain
    Contact Details: 

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  • Title: Incretin hormones, obesity and impaired glucose homeostasis: Bariatric surgery as a tool to study the role of incretin hormones in obesity and associated metabolic dysfunction
    Acronym: Bariatric
    Recruitment Site: Morriston Hospital
    Investigator: Prof J Stephens
    Contact Details: 

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  • Title: Pemafibrate to reduce cardiovascular outcomes by reducing triglycerides in patients with diabetes
    Acronym: PROMINENT
    Recruitment Site: Singleton Hospital
    Investigator: Prof S Bain
    Contact Details: 

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  • Title: Phenotyping the Brecon Cohort of childhood-onset Type 1 Diabetes to identify those at risk of adverse long-term outcomes who may in future merit immunotherapeutic intervention at diagnosis: a feasibility study
    Acronym: Phenotyping the Brecon Cohort
    Recruitment Site: Princess of Wales Hospital
    Investigator: Ms Mandy Cook; Dr Nirupa D'Souza
    Contact Details: 

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  • Title: Proinsulin in the Diagnosis and Risk Stratification of Gestational Diabetes Mellitus
    Acronym: Proinsulin in GDM
    Recruitment Site: Joint Clinical Research Facility
    Investigator: Dr R Peter
    Contact Details: 

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  • Title: SoMoR - UK (Study of Management of RAASi in UK). A multi-centre, retrospective observational study on renin-angiotensin-aldosterone system inhibitors (RAASi) management in patients treated for chronic kidney disease alongside heart failure and/or type 2 diabetes mellitus
    Acronym: SoMoR
    Recruitment Site: Morriston Hospital
    Investigator: 
    Contact Details: 

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  • Title: StartRight: Getting the right classification and treatment from diagnosis in young adults with diabetes
    Acronym: StartRight Study
    Recruitment Site: Morriston Hospital
    Investigator: Prof S Bain
    Contact Details: 

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  • Title: Study of the genetics of Severe Insulin Resistance
    Acronym: SIRS
    Recruitment Site: Singleton Hospital
    Investigator: 
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  • Title: T Cell studies in type 1 diabetes
    Acronym: T cell studies in T1D
    Recruitment Site: Morriston Hospital
    Investigator: 
    Contact Details: 

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  • Title: The Genetic Basis of Severe Childhood Obesity
    Acronym: Genetics of Obesity
    Recruitment Site: Morriston Hospital; Neath Port Talbot Hospital; Princess of Wales Hospital; Singleton Hospital
    Investigator: Dr C Bidder; Dr M Cosgrove; Dr N D'Souza; Dr R Pryce
    Contact Details: 

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  • Title: The role of habitual physical activity and sedentary time on cardiovascular health and metabolic control for children and adolescents with type 1 diabetes mellitus
    Acronym: 
    Recruitment Site: Morriston Hospital
    Investigator: Dr C Bidder
    Contact Details: 

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  • Title: TriMaster: Randomised Double-Blind Crossover Study of a DPP4 Inhibitor, SGLT2 Inhibitor and Thiazolidinedione as Third Line Therapy in Patients with Type 2 Diabetes who have Suboptimal Glycaemic Control on Dual Therapy with Metformin and Sulphonylurea
    Acronym: TriMaster
    Recruitment Site: Morriston Hospital
    Investigator: Prof S Bain
    Contact Details: 

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  • Title: 4222: Efficacy and long-term safety of oral semaglutide versus sitagliptin in subjects with type 2 diabetes mellitus. A 78-week, randomised, double-blind, double-dummy, active-controlled, parallel-group, multi-centre, multi-national, four-armed trial
    Acronym: Pioneer 3
    Recruitment Site: Joint Clinical Research Facility
    Investigator: Prof S Bain
    Contact Details: 

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  • Title: A 16-week, open-label, randomized, active-controlled, parallel-group, multi-center study evaluating effectiveness, ease of use and safety of a device-supported treat-to-target regimen versus routine self-titration in T2DM patients treated with the study drug
    Acronym: DIAB 3902
    Recruitment Site: Singleton Hospital
    Investigator: Prof S Bain
    Contact Details: 

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  • Title: A 24-week, Multicenter, Randomized, Open-label, Parallel-group Study Comparing the Efficacy and Safety of Toujeo and Tresiba in Insulin-Naive Patients with Type 2 Diabetes Mellitus Not Adequately Controlled with Oral Antihyperglycaemic Drug(s) ±GLP-1 receptor agonist
    Acronym: DIAB 5124
    Recruitment Site: Morriston Hospital
    Investigator: Prof J Stephens
    Contact Details: 

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  • Title: A multicentre, international, randomised, parallel group, double blind study to evaluate Cardiovascular safety of linagliptin versus glimepiride in patients with type 2 diabetes mellitus at high cardiovascular risk.(CAROLINA).
    Acronym: CAROLINA
    Recruitment Site: Morriston Hospital
    Investigator: Prof S Bain; Prof J Stephens
    Contact Details: 

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  • Title: A Multicentre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Dapagliflozin as an Add-on to Insulin Therapy in Subjects with Type 1 Diabetes Mellitus - Study Two
    Acronym: DEPICT-2
    Recruitment Site: Joint Clinical Research Facility
    Investigator: Prof S Bain
    Contact Details: 

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  • Title: A Multinational, Randomised, Double-Blind, Placebo-Controlled Trial to Evaluate the Effect of Ticagrelor 90mg twice daily on the Incidence of Cardiovascular Death, Myocardial Infarction or Stroke in Patients with Type 2 Diabetes Mellitus
    Acronym: DRN 2884 (THEMIS)
    Recruitment Site: Joint Clinical Research Facility
    Investigator: Prof S Bain
    Contact Details: 

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  • Title: A Randomized, Double-blind, Event-driven, Placebo-controlled, Multicenter Study of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Subjects with Type 2 Diabetes Mellitus and Diabetic Nephropathy
    Acronym: The CREDENCE Trial
    Recruitment Site: Singleton Hospital; St Thomas & West Cross Surgery
    Investigator: Prof J Stephens
    Contact Details: 

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  • Title: A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects with Type 2 Diabetes
    Acronym: Pioneer 6
    Recruitment Site: Singleton Hospital
    Investigator: Prof S Bain
    Contact Details: 

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  • Title: Access to Transplantation and Transplant Outcome Measures
    Acronym: ATTOM version 1
    Recruitment Site: Morriston Hospital
    Investigator: Dr A Williams
    Contact Details: 

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  • Title: Albiglutide + Insulin Glargine Versus Insulin Lispro + Insulin Glargine in the Treatment of Subjects with Type 2 Diabetes Mellitus: The Switch Study
    Acronym: The Switch Study
    Recruitment Site: Joint Clinical Research Facility
    Investigator: Prof S Bain
    Contact Details: 

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  • Title: An Open-Label, Randomized, Multi-Center, Parallel-Group clinical Trial Comparing the Efficacy and Safety of Mylan's insulin Glargine with Lantus in Type 1 Diabetes Mellitus patients
    Acronym: INSTRIDE
    Recruitment Site: Morriston Hospital
    Investigator: Prof J Stephens
    Contact Details: 

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  • Title: Clinical Proof-of-Principle Trial in Adult Subjects with Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of NNC01114-0006 and Liraglutide on Preservation of Beta-Cell Function
    Acronym: DIAB 3796
    Recruitment Site: Singleton Hospital
    Investigator: Prof S Bain
    Contact Details: 

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  • Title: DRAKO - An observational study to assess the effectiveness of intravitreal aflibercept in routine clinical practice in patients with visual impairment due to diabetic macular oedema (DMO)
    Acronym: DRAKO Non-Interventional Study
    Recruitment Site: Joint Clinical Research Facility
    Investigator: 
    Contact Details: 

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  • Title: Evidence into practice: evaluating a child-centred intervention for diabetes medicine management
    Acronym: EPIC Project
    Recruitment Site: Singleton Hospital
    Investigator: 
    Contact Details: 

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  • Title: Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk
    Acronym: FOURIER
    Recruitment Site: Morriston Hospital; Singleton Hospital
    Investigator: Prof S Bain
    Contact Details: 

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  • Title: Ghrelin mediated lipid retention and insulin resistance in human visceral adipose tissue
    Acronym: Adipose tissue and Ghrelin Version 1
    Recruitment Site: Morriston Hospital
    Investigator: Prof J Stephens
    Contact Details: 

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  • Title: SPARTA: Effectiveness of Toujeo in treating type 1 diabetes
    Acronym: SPARTA
    Recruitment Site: Singleton Hospital
    Investigator: Prof S Bain
    Contact Details: 

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  • Title: The Effect of LY2189265 on Major Cardiovascular Events in Patients with Type 2 Diabetes: Reducing Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND)
    Acronym: DRN597 (REWIND)
    Recruitment Site: Morriston Hospital
    Investigator: Prof J Stephens
    Contact Details: 

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  • Title: The Impact of Severe Hypoglycaemic Events Requiring Interventions In Patients with Type 1 Diabetes Patients Treated Insulin Therapy
    Acronym: DIAB 4340
    Recruitment Site: Singleton Hospital
    Investigator: Prof S Bain
    Contact Details: 

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Research Centre/s

JCRF Swansea
Institute of Life Science 2
Swansea University
Singleton Campus
Swansea SA2 8PP

Contact:
Caroline Parsley
T: 01792 606413
E: caroline.parsley@wales.nhs.uk

Clinical Research Unit Morriston Hospital
Heol Maes Eglwys
Morriston
Swansea
SA6 6NL

Contact:
Claire Fagan
T: 01792 703722
E: claire.fagan@wales.nhs.uk

R & D Contact:

T: 01792 704056
E: abm.rd@wales.nhs.uk