Heath and Care Research Wales Supported Studies

 

Health and Care Research Wales is the delivery arm and external brand of the Welsh Government’s Health and Social Services Research & Development Division. Health and Care Research Wales works in partnership with the NHS, universities, local government, other research funders, patients and the public to fund, support and increase research that can transform lives, promotes economic growth and advance science. 

 

The Diabetes Research Group Swansea Laboratory is providing lab support to:

 

The CLOuD Study

Closed Loop from Onset in type 1 Diabetes - ‘CLOuD’ Assessing the effect of closed loop insulin delivery from onset of T1DM in youth on residual beta-cell function versus standard insulin therapy

  • NIHR EME funded study
  • Multicentre study aiming to recruit approximately 100 participants
  • Newly diagnosed with T1DM and aged less than 18
  • Each participant in study for 2 years (plus 1 year extension)

 

The Diabetes Research Group Swansea Laboratory is

  • providing sample collection equipment (tubes, labels, lab manuals etc)
  • Organising periodic frozen sample collection from sites using courier service
  • Analysing HbA1c (every 3 months) and C-peptide and glucose from MMTT (every 6 months)

 

Find out more about the study http://cloud.mrl.ims.cam.ac.uk/

 

The USTEKID Study

USTEKID study Phase II multi-centre, double-blind, randomised trial of Ustekinumab in adolescents with new-onset type 1 diabetes to determine the efficacy of Ustekinumab for preserving Mixed Meal Tolerance Test (MMTT) stimulated 2-hour insulin C-peptide area under the curve (AUC) at week 52 as compared to placebo.

  • NIHR EME funded study
  • Multicentre study aiming to recruit approximately 72 participants
  • Newly diagnosed with T1DM and aged less than 18
  • Dosed within first 100 days of diagnosis

 

Diabetes Research Group Swansea Laboratory is

  • measuring eligibility screening samples for beta-cell autoantibodies and MMTT C-peptide levels
  • Batch analysing additional autoantibody samples, HbA1c, MMTT samples and dried blood spot C-peptide levels

 

Find out more about the https://www.type1diabetesresearch.org.uk/current-trials/ustekid/